Acylsulfonamide

Acylsulfonamide is a functional group in organic chemistry that is sometimes used in medicinal chemistry.^[1] It consists of a sulfonamide group (SO₂NH) linked to an acyl group (RCO), forming the structure R−CO−NH−SO₂−R′. This moiety is found in several biologically active molecules and marketed drugs, serving as an useful pharmacophore.^[2] Acylsulfonamides are of particular interest due to their ability to act as bioisosteres of carboxylic acids, offering similar hydrogen bonding capabilities and comparable pKa values (typically between 3.5–4.5).^[2] They are incorporated in various drugs candidates targeting conditions such as bacterial infections, pain, and cancer.^[3]