Adaptor complexes medium subunit domain
Protein family
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In molecular biology, the adaptor complexes medium subunit domain is a protein domain found at the C-terminus of the mu subunit from various clathrin adaptor protein complexes (AP1, AP2, AP3, AP4 and AP5)[1] and muniscins. The C-terminal domain has an immunoglobulin-like beta-sandwich fold consisting of 9 strands in 2 sheets with a Greek key topology, similar to that found in cytochrome f and certain transcription factors.[2] The mu subunit regulates the coupling of clathrin lattices with particular membrane proteins by self-phosphorylation via a mechanism that is still unclear.[3] The mu subunit possesses a highly conserved N-terminal domain of around 230 amino acids, which may be the region of interaction with other AP proteins; a linker region of between 10 and 42 amino acids; and a less well-conserved C-terminal domain of around 190 amino acids, which may be the site of specific interaction with the protein being transported in the vesicle.[3]
| Adap_comp_sub | |||||||
|---|---|---|---|---|---|---|---|
mu2 adaptin subunit (ap50) of ap2 adaptor (second domain), complexed with ctla-4 internalization peptide ttgvyvkmppt | |||||||
| Identifiers | |||||||
| Symbol | Adap_comp_sub | ||||||
| Pfam | PF00928 | ||||||
| Pfam clan | CL0448 | ||||||
| InterPro | IPR008968 | ||||||
| PROSITE | PDOC00761 | ||||||
| SCOP2 | 1bxx / SCOPe / SUPFAM | ||||||
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