Addy Pross

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Addy Pross (born 1945) is an Israeli academic and author who is Emeritus Professor of chemistry at the Ben-Gurion University of the Negev. His research interests lie in Theoretical chemistry, the physics-chemistry-biology relationship and the origin of life.[1]

Born1945 (age 8081)
Tel Aviv, Palestine (now Israel)
KnownforWhat Is Life? How Chemistry Becomes Biology
FieldsChemistry, origin of life
Quick facts Born, Education ...
Addy Pross
Born1945 (age 8081)
Tel Aviv, Palestine (now Israel)
EducationUniversity of Sydney
Known forWhat Is Life? How Chemistry Becomes Biology
Scientific career
FieldsChemistry, origin of life
InstitutionsStanford University, Lund University, Ben Gurion University, New York University Shanghai
Doctoral advisorSever Sternhell
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Born in Tel Aviv in 1945, Pross attended University of Sydney, receiving his B.A. with First Class Hons. in 1966 and then a Ph.D in Organic chemistry in 1970 under Sever Sternhell. He worked as a visiting professor at Stanford University and Lund University before being appointed professor of chemistry at the Ben Gurion University in 1986. Pross has also served as a Visiting Professor in a number of universities including Rutgers University, University of Auckland and as an ARC Professorial Fellow at Sydney University.[2]

In 2004 Pross co-authored with Vladimir Khodorkovsky a research paper called "Extending the concept of kinetic stability: toward a paradigm for life" which was published in the Journal of Physical Organic Chemistry.[3] With regard to the Genes-first hypothesis he argued that though unlikely, the emergence of a replicating system that then develops metabolism is more likely than the emergence of a metabolic system that becomes replicative or a replicative metabolic system.[4]

In 2010 Pross became a member of the editorial board at Life (journal). His 2012 book What Is Life? How Chemistry Becomes Biology was published by Oxford University Press[5] and has been produced in nearly a dozen languages.[6] Regarding a definition of life Pross has come to see both life and Abiogenesis as processes governed by the laws of chemistry.[7]

In 2014 Pross started working as a visiting professor at New York University Shanghai. In 2023 the book Evolution "On Purpose": Teleonomy in Living Systems co-edited by Pross along with Peter Corning, Stuart Kauffman, Denis Noble, James A. Shapiro and Richard I. Vane-Wright stated in the introduction that "Teleonomy in living systems is not, after all, only "apparent". It is a fundamental fact of life."[8] In 2024 Pross appeared on Sean M. Carroll's Mindscape podcast.[9]

Publications

Books

  • Addy Pross (2012) What is Life?: How Chemistry Becomes Biology Oxford University Press
  • Addy Pross (1995) Theoretical and Physical Principles of Organic Reactivity Willey[10]

Journal articles

  • A Pross, R Pascal (2023) On the emergence of autonomous chemical systems through dissipation kinetics Life 13 (11), 2171
  • R Pascal, A Pross (2023) Mind from Matter: The Chemical Connection Israel Journal of Chemistry 63 (7-8), e202300038
  • R Pascal, A Pross (2022) On the chemical origin of biological cognition Life 12 (12), 2016
  • A Pross, R Pascal (2022) Dynamic kinetic stability: Toward the physicalization of biology APS March Meeting Abstracts 2022, A14. 001
  • A Pross (2021) How was Nature able to discover its own Laws — Twice? Life 11 (7), 679
  • A Pross (2020) COVID‐19, Globalization, De‐globalization and the Slime Mold's Lessons for Us All Israel journal of chemistry 60 (8-9), 905-906
  • A Pross (2019) Seeking to uncover Biology's Chemical Roots Emerging topics in life sciences 3 (5), 435-443
  • R Pascal, A Pross (2019) Chemistry’s kinetic dimension and the physical basis for life Journal of Systems Chemistry 7 (1), 1–8
  • A Pross (2018) Early life on Earth: Tracing the Chemical Path from Non-living to Living Proceedings of the International Astronomical Union 14 (S345), 206-214
  • A Pross (2018) Purpose & Desire: What Makes Something “Alive” and Why Modern Darwinism Has Failed to Explain It The Quarterly Review of Biology 93 (1), 18-19
  • A Pross, R Pascal (2017) How and why kinetics, thermodynamics, and chemistry induce the logic of biological evolution Beilstein journal of organic chemistry 13 (1), 665-674
  • R Pascal, A Pross (2017) A roadmap toward synthetic protolife Synlett 28 (01), 30-35
  • R Pascal, A Pross (2016) The logic of life Origins of Life and Evolution of Biospheres 46 (4), 507-513
  • A Pross (2016) Physical organic chemistry and the origin of life problem: A personal perspective Israel Journal of Chemistry 56 (1), 83-88
  • G Ashkenasy, A Pross (2015) Origin of Life: Special Issue Honoring Prof. Albert Eschenmoser on the Occasion of his 90th Birthday Israel Journal of Chemistry 55 (8), 835-836
  • R Pascal, A Pross (2015) Stability and its manifestation in the chemical and biological worlds Chemical Communications 51 (90), 16160-16165
  • R Pascal, A Pross (2014) The nature and mathematical basis for material stability in the chemical and biological worlds Journal of Systems Chemistry 5 (1), 3
  • R Pascal, A Pross, JD Sutherland (2013) Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics Open Biology 3 (11), 130156
  • A Pross (2013) Dynamic kinetic stability (DKS) as a conceptual bridge linking chemistry to biology Current Organic Chemistry 17 (16), 1702-1703
  • A Pross (2013) The evolutionary origin of biological function and complexity Journal of molecular evolution 76 (4), 185-191
  • A Pross, R Pascal (2013) The origin of life: what we know, what we can know and what we will never know Open biology 3 (3), 120190
  • A Pross (2012) How does biology emerge from chemistry? Origins of Life and Evolution of Biospheres 42 (5), 433-444
  • R Armon, U Charpa, E Davidson, U Deichmann, R Falk, J Glass, S Glick, M Laubichler, M Morange, I Nevo, A Pross, S Roth, V Shoshan-Barmatz (2012) Final Discussion: Issues and Challenges for the Future Perspectives in Biology and Medicine 55 (4), 608-611
  • A Pross (2011) Toward a general theory of evolution: Extending Darwinian theory to inanimate matter Journal of Systems Chemistry 2 (1), 1
  • N Wagner, A Pross (2011) The nature of stability in replicating systems Entropy 13 (2), 518-527
  • A Pross (2010) Commentary on "life as a unity or confederacy" Origins of Life and Evolution of the Biosphere 40, 478-480
  • A Pross (2010) Commentary on "plausibility of an RNA World" Origins of Life and Evolution of the Biosphere 40, 434-437
  • N Wagner, A Pross, E Tannenbaum (2010) Selection advantage of metabolic over non-metabolic replicators: a kinetic analysis Biosystems 99 (2), 126-129
  • A Pross (2009) Seeking the chemical roots of Darwinism: bridging between chemistry and biology Chemistry: A European Journal 15 (34), 8374-8381
  • A Pross (2008) How can a chemical system act purposefully? Bridging between life and non‐life Journal of Physical Organic Chemistry 21 (7‐8), 724-730
  • A Pross (2008) How can a chemical system act purposefully Bridging between life and non-life. J
  • A Pross (2005) On the chemical nature and origin of teleonomy Origins of Life and Evolution of Biospheres 35 (4), 383-394
  • A Pross (2005) On the emergence of biological complexity: life as a kinetic state of matter Origins of Life and Evolution of Biospheres 35 (2), 151-166
  • A Pross (2005)Stability in chemistry and biology: Life as a kinetic state of matter Pure and Applied Chemistry 77 (11), 1905-1921
  • A Pross (2004) Causation and the origin of life. Metabolism or replication first? Origins of Life and Evolution of the Biosphere 34 (3), 307-321
  • A Pross, V Khodorkovsky (2004) Extending the concept of kinetic stability: toward a paradigm for life Journal of physical organic chemistry 17 (4), 312-316
  • ML Coote, A Pross, L Radom (2004) Understanding Alkyl Substituent Effects in RO Bond Dissociation Reactions in Open-and Closed-Shell Systems Fundamental World of Quantum Chemistry: A Tribute to the Memory of Per-Olov
  • ML Coote, A Pross, L Radom (2003) Variable Trends in R−X Bond Dissociation Energies (R = Me, Et, i-Pr, t-Bu) Organic Letters 5 (24), 4689-4692
  • A Pross (2003) The driving force for life's emergence: kinetic and thermodynamic considerations Journal of theoretical Biology 220 (3), 393-406
  • TI Sølling, A Pross, L Radom (2001) A high-level ab initio investigation of identity and nonidentity gas-phase SN2 reactions of halide ions with halophosphines International Journal of Mass Spectrometry 210, 1-11
  • L Radom, MW Wong, A Pross (1998) Radical Addition to Alkenes: A Theoretical Perspective
  • L Radom, MW Wong, A Pross (1997) Theoretical aspects of radical reactions American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
  • L Radom, MW Wong, A Pross, JPA Heuts, RG Gilbert (1997) Theoretical aspects of free radical reactions Abstracts of Papers of the American Chemical Society 213, 260-260
  • MN Glukhovtsev, A Pross, HB Schlegel, RD Bach, L Radom (1996) Gas-Phase Identity SN2 Reactions of Halide Anions and Methyl Halides with Retention of Configuration Journal of the American Chemical Society 118 (45), 11258-11264
  • MN Glukhovtsev, S Laiter, A Pross (1996 )Thermochemical assessment of the aromatic and antiaromatic characters of the cyclopropenyl cation, cyclopropenyl anion, and cyclopropenyl radical: A high-level computational study The Journal of Physical Chemistry 100 (45), 17801-17806
  • JPA Heuts, A Pross, L Radom (1996) Hydrogen transfer between ethyl radical and ethylene: An example where kinetics does not follow thermodynamics The Journal of Physical Chemistry 100 (43), 17087-17089
  • MN Glukhovtsev, RD Bach, A Pross, L Radom (1996) The performance of B3-LYP density functional theory in describing SN2 reactions at saturated carbon Chemical physics letters 260 (5-6), 558-564
  • MN Glukhovtsev, A Pross, L Radom (1996) Gas-Phase Non-Identity SN2 Reactions of Halide Anions with Methyl Halides:  A High-Level Computational Study Journal of the American Chemical Society 118 (26), 6273-6284
  • MN Glukhovtsev, A Pross, MP McGrath, L Radom (1996) Erratum: Extension of Gaussian-2 (G2) theory to bromine-and iodine-containing molecules: Use of effective core potentials The Journal of Chemical Physics 104 (9), 3407
  • MN Glukhovtsev, A Pross, L Radom (1996) Acidities, proton affinities, and other thermochemical properties of hypohalous acids HOX (X= F− I): A high-level computational study The Journal of Physical Chemistry 100 (9), 3498-3503
  • A Pross, H Zipse (1996) Theoretical and Physical Principles of Organic Reactivity Angewandte Chemie-English Edition 35 (16), 1866-1866
  • A Pross (1995) Theoretical and physical principles of organic reactivity (No Title)
  • MN Glukhovtsev, A Pross, L Radom (1995) Gas-phase identity SN2 reactions of halide ions at neutral nitrogen: A high-level computational study Journal of the American Chemical Society 117 (35), 9012-9018
  • MN Glukhovtsev, A Pross, MP McGrath, L Radom (1995) Extension of Gaussian‐2 (G2) theory to bromine‐and iodine‐containing molecules: Use of effective core potentials The Journal of chemical physics 103 (5), 1878-1885
  • MN Glukhovtsev, S Laiter, A Pross (1995) Thermochemistry of cyclobutadiene and tetrahedrane: A high-level computational study The Journal of Physical Chemistry 99 (18), 6828-6831
  • MN Glukhovtsev, A Pross, L Radom (1995) Gas-phase identity SN2 reactions of halide anions with methyl halides: a high-level computational study Journal of the American Chemical Society 117 (7), 2024-2032
  • MN Glukhovtsev, A Pross, A Nicolaides, L Radom (1995) Is the most stable gas-phase isomer of the benzenium cation a face-protonated π-complex? Journal of the Chemical Society, Chemical Communications, 2347-2348
  • MN Glukhovtsev, JE Szulejko, TB McMahon, JW Gauld, AP Scott, B J Smith, A Pross, L Radom (1994) New theoretical and experimental proton affinities for methyl halides and diazomethane: A revision of the methyl cation affinity scale The Journal of Physical Chemistry 98 (50), 13099-13101
  • MW Wong, A Pross, L Radom (1994) Addition of tert-butyl radical to substituted alkenes: a theoretical study of the reaction mechanism Journal of the American Chemical Society 116 (26), 11938-11943
  • MW Wong, A Pross, L Radom (1994) Comparison of the addition of CH3. bul., CH2OH. bul., and CH2CN. bul. Radicals to substituted alkenes: A theoretical study of the reaction mechanism Journal of the American Chemical Society 116 (14), 6284-6292
  • MN Glukhovtsev, A Pross, L Radom (1994) Is SN2 substitution with inversion of configuration at vinylic carbon feasible? Journal of the American Chemical Society 116 (13), 5961-5962
  • MW Wong, A Pross, L Radom (1994) The Mechanism of Radical-Addition to Alkenes Abstracts of Papers of The American Chemical Society 207, 242-ORGN
  • A Pross, SS Shaik, HB Schlegel, S Wolfe (1994) Theoretical Aspects of Physical Organic Chemistry. The SN2 Mechanism Journal of the American Chemical Society 116 (18), 8434-8434
  • S Shaik, A Ioffe, AC Reddy, A Pross (1994) Is the avoided crossing state a good approximation for the transition state of a chemical reaction? An analysis of Menschutkin and ionic SN2 reactions Journal of the American Chemical Society 116 (1), 262-273
  • MW Wong, A Pross, L Radom (1993) Are polar interactions important in the addition of methyl radical to alkenes? Journal of the American Chemical Society 115 (23), 11050-11051
  • MW Wong, A Pross, L Radom (1993) Addition of methyl radical to substituted alkenes: a theoretical study of the reaction mechanism Israel journal of chemistry 33 (4), 415-425
  • A Pross, S Shaik (1992) What is a Good Approximation for the Transition State of an SN2 Reaction? Croatica Chemica Acta 65 (3), 625-631
  • A Pross, H Yamataka, S Nagase (1991) Reactivity in radical abstraction reactions: Application of the curve crossing model Journal of physical organic chemistry 4 (3), 135-140
  • A Pross, RA Moss (1990) A curve crossing approach to carbenic reactivity Tetrahedron letters 31 (32), 4553-4556
  • SS Shaik, A Pross (1989) Nucleophilic attack on cation radicals and cations. A theoretical analysis Journal of the American Chemical Society 111 (12), 4306-4312
  • A Pross, SS Shaik (1987) Brønsted coefficients. Do they measure transition state structure? New Journal of Chemistry 13 (6), 427-433
  • AJ Shusterman, I Tamir, A Pross (1988) The mechanism of organometallic migration reactions. A configuration mixing (CM) approach Journal of Organometallic Chemistry 340 (2), 203-222
  • A Pross (1987) Relationship between Nucleophilic Reactions and Single-Electron Transfer: Application to Reactions of Radical Cations Nucleophilicity Chapter 23, 331-338
  • A Pross, DM Chipman (1987) The single-electron shift as a basis of organic reactivity Free Radical Biology and Medicine 3 (1), 55-64
  • A Pross (1986) Can nucleophiles attack radical cations directly? "Allowed" and "forbidden" polar reactions. Journal of the American Chemical Society 108 (12), 3537-3538
  • A Pross (1985) The single electron shift as a fundamental process in organic chemistry: the relationship between polar and electron-transfer pathways. Accounts of Chemical Research 18 (7), 212-219
  • A Pross (1985) Factors Governing the Competition Between Nucleophilic and Single-electron Transfer Processes. Abstracts of Papers of The American Chemical Society 190 (SEP), 92-ORN
  • A Pross (1985), Limitations of the Reactivity—Selectivity Principle. Application to Free Radical Addition to Alkenes and Nucleophilic Aliphatic Substitution. Israel Journal of Chemistry 26 (4) 390-394

References

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