Adenylyl-sulfate kinase
Protein family
From Wikipedia, the free encyclopedia
Adenylyl-sulfate kinase (EC 2.7.1.25) is an enzyme that catalyzes the chemical reaction
| Adenylylsulfate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Adenylylsulfate kinase homohexamer, Thiobacillus denitrificans | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.25 | ||||||||
| CAS no. | 9012-38-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme characterised from liver converts the adenosine monophosphate derivative, 5'-adenylyl sulfate, to 3'-phosphoadenosine-5'-phosphosulfate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2] The enzyme is also found in human brain.[3]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:adenylyl-sulfate 3'-phosphotransferase. Other names in common use include adenylylsulfate kinase (phosphorylating), 5'-phosphoadenosine sulfate kinase, adenosine 5'-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate-3'-phosphokinase, and APS kinase. It participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism.[4]
