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Adimolol

Chemical compound From Wikipedia, the free encyclopedia

Adimolol (developmental code name MEN-935) is antihypertensive agent which acts as a non-selective α1-, α2-, and β-adrenergic receptor antagonist.[1]

ATC code
  • none
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Adimolol
Clinical data
ATC code
  • none
Identifiers
  • 3-[3-[[2-hydroxy-3-(1-naphthyloxy)propyl]amino]-3-methyl-butyl]-1H-benzimidazol-2-one
CAS Number
PubChem CID
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UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H29N3O3
Molar mass419.525 g·mol−1
3D model (JSmol)
  • O=C2Nc1ccccc1N2CCC(NCC(O)COc4c3ccccc3ccc4)(C)C
  • InChI=1S/C25H29N3O3/c1-25(2,14-15-28-22-12-6-5-11-21(22)27-24(28)30)26-16-19(29)17-31-23-13-7-9-18-8-3-4-10-20(18)23/h3-13,19,26,29H,14-17H2,1-2H3,(H,27,30) checkY
  • Key:YWRIUGFSIQMHJK-UHFFFAOYSA-N checkY
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Synthesis

The reaction between 1-naphthyl glycidyl ether (1) and 3-(3-amino-3-methylbutyl)-1H-benzimidazol-2-one (2) gives adimolol (3).[2][3]

Synthesis of adimolol

References

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