Akuammine
Chemical compound
From Wikipedia, the free encyclopedia
Akuammine (vincamajoridine[2]) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida,[3] commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major.[2] Akuammine is structurally related to yohimbine, mitragynine and more distantly voacangine, all of which are alkaloid plant products.
| Names | |
|---|---|
| Other names
Vincamajoridine | |
| Identifiers | |
3D model (JSmol) |
|
| ChEMBL | |
| ChemSpider | |
PubChem CID |
|
| UNII | |
| |
| |
| Properties | |
| C22H26N2O4 | |
| Molar mass | 382.460 g·mol−1 |
| Melting point | 225 °C (437 °F; 498 K)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Pharmacology
Akuammine has antimalarial activity,[3] and may be the primary constituent of P. nitida seeds responsible for this activity.[4]
Akuammine is an opioid agonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.[5][6]
