Muchanga's career has included serving as Permanent Secretary for Parliamentary Affairs in his home country of Zambia and as Ambassador to Ethiopia and Brazil. He has also served as Deputy Executive Secretary of the Southern African Development Community (SADC).
On 30 January 2016, his first term as Commissioner for Trade and Industry began. In this capacity, Muchanga attended the South-South Cooperation Conference, a UN-supported initiative of the countries of the Global South, in Buenos Aires in March 2019. On the sidelines of the conference, Muchanga also met with Achim Steiner, the head of the United Nations Development Programme (UNDP).[1][2]
In 2021, Muchanga was re-elected as AU Commissioner for a term of four years with 44 out of 53 votes. In addition to trade and industry, he has since then also been responsible for the previously separate area of economic affairs (Commissioner for Economic Development, Trade, Industry and Mining), as a result of the reduced number of commissioners.