Alezzandrini syndrome

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SymptomsLoss of vision, facial vitiligo, sound sensitivity
CausesUnknown
TreatmentNone
Alezzandrini syndrome
SpecialtyDermatology
SymptomsLoss of vision, facial vitiligo, sound sensitivity
CausesUnknown
TreatmentNone
DeathsUnknown

Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerative retinitis, followed after several months by ipsilateral vitiligo on the face and ipsilateral poliosis.[1]:864[2] Deafness may also be present.[1]:864[3]

Initially, there is a progressive loss of visual acuity, mostly in one eye. Infected areas experience pigmentation loss in the skin and hair. Unilateral tapetoretinal degeneration accompanied by the ipsilateral appearance of facial vitiligo and poliosis is the hallmark of Alezzandrini syndrome.[4]

Causes

It is unknown what causes Alezzandrini syndrome.[4]

Diagnosis

The clinical presentation is the basis for the diagnosis.[4]

Treatment

Psoralen plus ultraviolet A (PUVA) treatment is an option for cases with extensive depigmentation. Topical steroids may be used to treat vitiligo in specific areas. People who have vitiligo should wear sunscreen to avoid getting sunburned and developing skin cancer later on.[4]

See also

References

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