Mir Sahib was born on 31 August 1915 in his hometown Tando Mir Mahmood Hyderabad, Sindh in the house of Mir Nabi Bakhsh Khan Talpur. He started his political career when he joined Jamiat Ulema-e-Hind in 1936. Later in 1939, he joined Khaksar movement when Inayatullah Khan Mashriqi invited him. When Mashriqui was imprisoned in 1941, Talpur was elected as the acting head of the movement for the 22 months. However, in 1944 he disassociated himself from the movement after Allama wrote a letter to him concerning his role in forming Fidayeen-e-Ameer (Islamic military organisation) in Sindh against the movement, and he subsequently joined the Indian National Congress to participate in the Indian independence movement. He allegedly opposed the partition of India. When Pakistan was formed as a sovereign state in 1947, he was imprisoned for six months under court-martial law.[2]
He was among the five cabinet ministers to support Zia's campaign for Islamic law enforcement in Pakistan.[4]
He had been living in London for the purpose of treatment since October 1986, where he died on 5 April 1987.
Mir's body was brought back to country and buried in his ancestral graveyard "Ganju Takkar" in Hyderabad, Sindh on 8 April 1987. President of the country, Provincial Governors high military and senior civil officials and Political and social figures participated in Mir Sahib's funeral prayer, the prayer was led by Moulana Muhammad Ali Rezvi, ex:MNA. Sindh Jo Syed Sain G.M Syed was also present on this time.
