Alkene monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Alkene monooxygenase (EC 1.14.13.69) is an enzyme that catalyzes the chemical reaction
| Alkene monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.69 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are propylene, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are propylene oxide, oxidised NAD+, and water.[1][2]
This enzyme is an oxidoreductase, acting on paired donors, with molecular oxygen as oxidant and incorporating one of its atoms. The systematic name of this enzyme class is alkene,NADH:oxygen oxidoreductase. This enzyme is also called alkene epoxygenase. It contains a Rieske type of ferredoxin.[3][4]
Substrate range
The enzyme from a Xanthobacter bacterial species has four peptide components, all of which are required for activity. These oxidise a large range of double bonds, including internal or terminal alkenes and chlorinated derivatives.[5]
When propene is the substrate, the epoxide product is 95% the (R) enantiomer.[6]
