Alkyl-lysophospholipids
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Alky-lysophospholipids (ALPs) are synthetic analogs of lysophosphatidylcholines (LPCs), also called lysolecithins. They are synthesized by replacing the acyl-group within the LPC with an alkyl group.[1] In contrast to LPCs, ALPs are metabolically very stable.[1][2]
ALPs are being studied for their potential antineoplastic (anti-cancer)[1] and immune-modulating effects.[2] Their anti-tumor effects are due to modulation of intracellular signalling pathways, inducing apoptosis.[3] It is highly selective, sparing healthy cells.[2] Several examples including edelfosine, miltefosine, and perifosine are under development as drugs against cancer and other diseases.