Aminocarboxymuconate-semialdehyde decarboxylase
Class of enzymes
From Wikipedia, the free encyclopedia
The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction:[1]
| aminocarboxymuconate-semialdehyde decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 aminocarboxymuconate-semialdehyde decarboxylase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.1.45 | ||||||||
| CAS no. | 37289-47-7 | ||||||||
| Alt. names | ACMSD | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The product spontaneously ring-closes to picolinic acid, with loss of water.[2][3]
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. This enzyme is part of the kynurenine pathway in tryptophan metabolism, leading to picolinic acid or quinolinic acid.[3] It has been identified as a marker in nonverbal autism.[4]
Nomenclature
The systematic name of this enzyme class is 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming). Other names in common use include picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde, beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, and 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase.[1]
