Aminolevulinate transaminase
From Wikipedia, the free encyclopedia
Aminolevulinate transaminase (EC 2.6.1.43) is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible chemical reaction
The two substrates of this enzyme characterised from Rhodopseudomonas spheroides are aminolevulinic acid and pyruvic acid. Its products are 4,5-dioxopentanoic acid and L-alanine.[1][2] Although aminolevulinic acid is an intermediate in the pathway to heme, via protoporphyrinogen IX, the main biosynthetic pathway to it in Rhodopseudomonas spheroides is via glycine and succinyl coenzyme A.[3]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is 5-aminolevulinate:pyruvate aminotransferase. Other names in common use include aminolevulinate aminotransferase, gamma,delta-dioxovalerate, aminotransferase, gamma,delta-dioxovaleric acid transaminase, 4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric transaminase, 5-aminolevulinic acid transaminase, alanine-gamma,delta-dioxovalerate aminotransferase, alanine-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, aminolevulinic acid transaminase, dioxovalerate transaminase, L-alanine-4,5-dioxovalerate aminotransferase, L-alanine:4,5-dioxovaleric acid transaminase, L-alanine:dioxovalerate transaminase, DOVA transaminase, and 4,5-dioxovaleric acid aminotransferase.[4]
