Mezulis' research is supported by organizations such as the National Institute of Mental Health and the American Psychological Association.[2][1] Her research examines the interplay of environment and biology in mental health.[2] With over 50 peer-reviewed studies, her focus lies in adolescent depression, self-injury, and other clinical disorders.[2][10] Her therapeutic approach emphasizes stress management, regulation of emotions, and addressing issues such as eating, sleeping, and trauma.[2]
In 2001, a study conducted by Janet Shibley Hyde and Mezulis reached the conclusion that gender differences are often minimal and infrequent in comparison to the significant similarities between the sexes.[11][12]
In a 2004 meta-analysis encompassing 266 studies, Mezulis and her fellow researchers identified significant cross-cultural differences in self-serving bias.[13] The findings revealed that Asians exhibit considerably smaller biases compared to Westerners.[13] In the same study, Mezulis and her team identified a "self-serving" bias trend, where individuals attribute positive events to internal, stable causes more than negative ones. This bias was less evident in those with psychological illnesses, suggesting reduced psychological benefits from positive interpretations.[14]