Anthranilate N-methyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
Anthranilate N-methyltransferase (EC 2.1.1.111) is an enzyme that catalyzes the chemical reaction
| Anthranilate N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.111 | ||||||||
| CAS no. | 123779-15-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This is a methylation reaction in which the anthranilic acid is converted to N-methylanthranilic acid. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Ruta graveolens.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:anthranilate N-methyltransferase. It is also called anthranilic acid N-methyltransferase.[2] The reaction is the first step specific to the biosynthesis of acridone alkaloids.[1]
