Apararenone

Apararenone (INN; development code MT-3995) is a nonsteroidal antimineralocorticoid which is under development by Mitsubishi Tanabe Pharma for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.^[1][2][3] It was also previously being developed for the treatment of hypertension, but development was discontinued for this indication.^[1] Apararenone acts as a highly selective antagonist of the mineralocorticoid receptor (K_i < 50 nM), the receptor for aldosterone.^[1][2][3] As of 2017, it is in phase II clinical trials.^[1]

Other namesMT-3995

Routes of
administrationOral

Drug classAntimineralocorticoid

CAS Number

• 945966-46-1

Quick facts Clinical data, Other names ...

Apararenone

Clinical data
Other names	MT-3995
Routes of administration	Oral
Drug class	Antimineralocorticoid
Identifiers
IUPAC name N-[4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide
CAS Number	945966-46-1
PubChem CID	24744336
ChemSpider	28663572
UNII	832663U2NB
ChEMBL	ChEMBL2181929
Chemical and physical data
Formula	C17H17FN2O4S
Molar mass	364.39 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(C(=O)N(C2=C(O1)C=C(C=C2)NS(=O)(=O)C)C3=CC=C(C=C3)F)C
InChI InChI=1S/C17H17FN2O4S/c1-17(2)16(21)20(13-7-4-11(18)5-8-13)14-9-6-12(10-15(14)24-17)19-25(3,22)23/h4-10,19H,1-3H3 Key:AZNHWXAFPBYFGH-UHFFFAOYSA-N

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