Aquaporin-7

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.^[5][6]

AliasesAQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7

External IDsOMIM: 602974; MGI: 1314647; GeneCards: AQP7

Chr.Chromosome 9 (human)^[1]

End33,402,682 bp^[1]

Quick facts AQP7, Identifiers ...

AQP7
Identifiers
Aliases	AQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7
External IDs	OMIM: 602974; MGI: 1314647; GeneCards: AQP7
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 33,383,179 bp[1] End 33,402,682 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 41,033,074 bp[2] End 41,048,139 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart subcutaneous adipose tissue left ventricle sural nerve right auricle of heart muscle of thigh lactiferous gland gastric mucosa duodenum quadriceps femoris muscle Top expressed in spermatid seminiferous tubule brown adipose tissue aortic valve white adipose tissue proximal tubule right kidney tunica adventitia of aorta ascending aorta muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycerol channel activity water channel activity channel activity urea transmembrane transporter activity Cellular component cytoplasm integral component of membrane plasma membrane integral component of plasma membrane membrane cell-cell junction lipid droplet cell cortex cytoplasmic vesicle membrane cytoplasmic vesicle Biological process water transport excretion glycerol transport generation of precursor metabolites and energy transmembrane transport urea transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 364 11832 Ensembl ENSG00000165269 ENSMUSG00000028427 UniProt O14520 O54794 RefSeq (mRNA) NM_001170 NM_001318156 NM_001318157 NM_001318158 NM_001376191 NM_001376192 NM_001376193 NM_007473 RefSeq (protein) NP_001161 NP_001305085 NP_001305086 NP_001305087 NP_001363120 NP_001363121 NP_001363122 NP_031499 NP_001365567 NP_001365568 NP_001365569 NP_001365570 NP_001365571 Location (UCSC) Chr 9: 33.38 – 33.4 Mb Chr 4: 41.03 – 41.05 Mb PubMed search [3] [4]
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Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.^[6]