Aquaporin-8

Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.^[5][6][7]

AliasesAQP8, AQP-8, aquaporin 8

External IDsOMIM: 603750; MGI: 1195271; GeneCards: AQP8

Chr.Chromosome 16 (human)^[1]

End25,228,932 bp^[1]

Quick facts AQP8, Identifiers ...

AQP8
Identifiers
Aliases	AQP8, AQP-8, aquaporin 8
External IDs	OMIM: 603750; MGI: 1195271; GeneCards: AQP8
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 25,215,731 bp[1] End 25,228,932 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 67.42 cM Start 123,061,514 bp[2] End 123,067,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon body of pancreas mucosa of ileum rectum mucosa of sigmoid colon testicle pancreatic epithelial cell epithelium of colon islet of Langerhans cerebellar hemisphere Top expressed in left colon left lobe of liver lacrimal gland spermatocyte blastocyst yolk sac embryo parotid gland seminiferous tubule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function water channel activity channel activity Cellular component integral component of membrane plasma membrane apical part of cell integral component of plasma membrane membrane mitochondrion mitochondrial membranes Biological process ion transmembrane transport cellular response to cAMP water transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 343 11833 Ensembl ENSG00000103375 ENSMUSG00000030762 UniProt O94778 P56404 RefSeq (mRNA) NM_001169 NM_001109045 NM_007474 RefSeq (protein) NP_001160 NP_001102515 NP_031500 Location (UCSC) Chr 16: 25.22 – 25.23 Mb Chr 7: 123.06 – 123.07 Mb PubMed search [3] [4]
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Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-8 mRNA is found in pancreas and colon but not other tissues.^[7]