Knowles was elected as a Fellow of the American Physical Society in 2021, after a nomination from the APS Forum on Diversity and Inclusion, "for decades of advocacy, mentorship, and exemplary work to promote equity, diversity, and inclusion in physics, so that marginalized students can thrive".[5] Sigma Pi Sigma, the physics and astronomy honor society, gave Knowles their 2022 Outstanding Service Award, "for a career of steadfast dedication to supporting student with an interest in physics and astronomy as they find their home, for her work on inclusion within the community, and a devotion to the Sigma Pi Sigma pillars of fellowship and service".[6] She was named as a 2024 Fellow and a 2025 Black History Month Honoree of the National Society of Black Physicists, "for decades of visible and invisible advocacy, mentorship, and exemplary work around equity, diversity, and inclusion in physics learning spaces so that Black and other marginalized people, particularly students, can flourish and thrive".[2]