In 1903, Hopkins set up a missionary base in the Lau Lagoon under the orders of Charles Morris Woodford.[3] He was sent to the Lau Lagoon in order to preempt the possibility of the Methodist Church setting up a mission in the area, as the Anglican colonial authorities did not wish for the Methodists to gain influence.[4] After arriving at the mission he was placed under 24-hour guard, as the mission was under constant threat of attack from locals.[3]
Hopkins became influential in the area, negotiating the setting up of missions with Malaitan leaders.[5] He had strained relations with the most powerful leader in the area, Kwaisulia, but co-operated with him on crushing local outbreaks of violence.[6] Hopkins translated the Bible into the Lau and Kwara'ae languages, and also conducted church services in those languages.[1] He attempted to send copies of these translated religious materials to Pentecostal missionary Peter Ambuofa, but his efforts did not result in any significant conversions to Anglicanism in the area under Ambuofa's control.[7]