In 428 or 427 BC Sempronius held the consulship together with Lucius Quinctius Cincinnatus. This consulship is dubious as it is only mentioned by Diodorus Siculus and is placed in-between the consuls of 428, Aulus Cornelius Cossus and Titus Quinctius Poenus Cincinnatus, and the consuls of 427 BC, Gaius Servilius Structus Ahala and Lucius Papirius Mugillanus. It is possible that they were suffect consuls replacing the college of 428 BC or that all four consuls mentioned in 428 were consular tribunes.[3][4] All events described by other ancient authors are ascribed to the ordinary consuls of 428 BC.
Sempronius was elected as consular tribune in 425 BC together with (possibly his former consular colleague) Lucius Quinctius Cincinnatus, Lucius Furius Medullinus and Lucius Horatius Barbatus. They oversaw the signing of a twenty year truce with Veii and a three year truce with the Aequi.[5][6][7][8]
Sempronius was re-elected as consular tribune in 420 BC, sharing it with two of his former colleagues, Furius and Quinctius, and a consular newcomer, Marcus Manlius Vulso. In some sources the Quinctius who shared in the college was not Lucius Quinctius, but instead his brother Titus Quinctius Poenus Cincinnatus. Little is known of the events during the year other than that Sempronius presided over the election of the Quaestors.[5][9][10][11]
Sempronius again held the imperium as consular tribune in 416 BC. His colleagues were Marcus Papirius Mugillanus, Quintus Fabius Vibulanus and Spurius Nautius Rutilus. The only known event during the year was the proposal of an agrarian law by two of the Tribunes of the Plebs, which was vetoed by their own colleagues.[5][12][13][14][15]