Avadomide

Avadomide (CC-122) is an experimental cereblon E3 ligase modulator, or thalidomide analog (molecular glue) that was discovered and studied by Celgene to see if it was effective against cancer.^{[1][2][3][4][5]} The deuterated S-enantiomer, SP-3164 (DRX-164) is in development at Salarius Pharmaceuticals.^[6][7]

Legal status

• Investigational

CAS Number

• 1015474-32-4

PubChem CID

• 24967599

IUPHAR/BPS

• 10522

Quick facts Legal status, Identifiers ...

Avadomide

Legal status
Legal status	Investigational
Identifiers
IUPAC name 3-(5-Amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
CAS Number	1015474-32-4
PubChem CID	24967599
IUPHAR/BPS	10522
DrugBank	DB14857
ChemSpider	35521266
UNII	28DZS29F59
KEGG	D11132
ChEMBL	ChEMBL3989934
Chemical and physical data
Formula	C14H14N4O3
Molar mass	286.291 g·mol−1
3D model (JSmol)	Interactive image
SMILES Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O
InChI InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20) Key:RSNPAKAFCAAMBH-UHFFFAOYSA-N

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