Azelnidipine

Azelnidipine (INN; marketed under the brand name CalBlock — カルブロック) is a dihydropyridine calcium channel blocker. Azelnidipine is L and T calcium channel blocker. It is sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. Drug Controller General Of India (DCGI) has approved the use of azelnipine in India. It is launched under the brand name Azusa (ajanta pharma ltd.)^[1] In 2020.

Trade namesCalBlock, AZUSA, Azovas

AHFS/Drugs.comInternational Drug Names

Routes of
administrationOral

ATC code

• none

Quick facts Clinical data, Trade names ...

Azelnidipine

Clinical data
Trade names	CalBlock, AZUSA, Azovas
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 3-1-Benzhydryl-3-azetidinyl 5-isopropyl 2-amino-6-methyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	123524-52-7 N
PubChem CID	65948
ChemSpider	59352 Y
UNII	PV23P19YUG
KEGG	D01145 Y
ChEMBL	ChEMBL1275868 N
CompTox Dashboard (EPA)	DTXSID3020120
ECHA InfoCard	100.162.151
Chemical and physical data
Formula	C33H34N4O6
Molar mass	582.657 g·mol−1
3D model (JSmol)	Interactive image
SMILES [O-][N+](=O)c1cccc(c1)C5C(/C(=O)OC(C)C)=C(\NC(\N)=C5\C(=O)OC4CN(C(c2ccccc2)c3ccccc3)C4)C
InChI InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3 Y Key:ZKFQEACEUNWPMT-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Unlike nicardipine, it has a gradual onset and has a long-lasting antihypertensive effect, with little increase in heart rate.

Azelnidipine inhibits CYP2J2.^[2]