B115

Chemical compound From Wikipedia, the free encyclopedia

B115 (IUPAC name 1-methyl-4-[(E)-2-naphthalen-1-ylethenyl]-3,6-dihydro-2H-pyridine[1]) is an inhibitor of the enzyme choline acetyltransferase (ChAT).

Quick facts Names, Identifiers ...
B115
Names
IUPAC name
1-Methyl-4-[(E)-2-naphthalen-1-ylethenyl]-3,6-dihydro-2H-pyridine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C18H19N/c1-19-13-11-15(12-14-19)9-10-17-7-4-6-16-5-2-3-8-18(16)17/h2-11H,12-14H2,1H3/b10-9+
    Key: BPVAGRSEOWNGCE-MDZDMXLPSA-N
  • CN1CCC(=CC1)/C=C/C2=CC=CC3=CC=CC=C32
Properties
C18H19N
Molar mass 249.357 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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In vivo activity

B115 inhibits human ChAT with an IC50 of 4.3 μM.[2] During in vivo testing, B115 has been found to partially protect against soman, a nerve agent, but it has been suggested that this may not be due to ChAT inhibition.[3][4]

References

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