B4GALT3

Beta-1,4-galactosyltransferase 3 is an enzyme that in humans is encoded by the B4GALT3 gene.^[5][6][7]

AliasesB4GALT3, beta4Gal-T3, beta-1,4-galactosyltransferase 3

External IDsOMIM: 604014; MGI: 1928767; HomoloGene: 48241; GeneCards: B4GALT3; OMA:B4GALT3 - orthologs

Chr.Chromosome 1 (human)^[1]

End161,177,968 bp^[1]

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B4GALT3
Identifiers
Aliases	B4GALT3, beta4Gal-T3, beta-1,4-galactosyltransferase 3
External IDs	OMIM: 604014; MGI: 1928767; HomoloGene: 48241; GeneCards: B4GALT3; OMA:B4GALT3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,171,310 bp[1] End 161,177,968 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.29 cM Start 171,097,898 bp[2] End 171,104,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte granulocyte secondary oocyte anterior pituitary left ovary body of pancreas body of stomach right ovary spleen lymph node Top expressed in granulocyte yolk sac saccule neural layer of retina otic vesicle islet of Langerhans epithelium of lens otic placode Rostral migratory stream Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity N-acetyllactosamine synthase activity metal ion binding beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity galactosyltransferase activity Cellular component Golgi cisterna membrane Golgi membrane integral component of membrane membrane extracellular exosome Golgi apparatus cytosol Biological process protein glycosylation keratan sulfate biosynthetic process galactosylceramide biosynthetic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8703 57370 Ensembl ENSG00000158850 ENSMUSG00000052423 UniProt O60512 Q91YY2 RefSeq (mRNA) NM_001199873 NM_001199874 NM_003779 NM_020579 RefSeq (protein) NP_001186802 NP_001186803 NP_003770 NP_065604 Location (UCSC) Chr 1: 161.17 – 161.18 Mb Chr 1: 171.1 – 171.1 Mb PubMed search [3] [4]
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This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains.^[7]