BESS domain
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| BESS | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BESS | ||||||||
| Pfam | PF02944 | ||||||||
| InterPro | IPR004210 | ||||||||
| |||||||||
In molecular biology, the BESS domain is a protein domain which has been named after the three proteins that originally defined the domain: BEAF (Boundary element associated factor 32),[1] Suvar(3)7 [2] and Stonewall [3]). The BESS domain is 40 amino acid residues long and is predicted to be composed of three alpha helices, as such it might be related to the myb/SANT HTH domain. The BESS domain directs a variety of protein-protein interactions, including interactions with itself, with Dorsal, and with a TBP-associated factor. It is found in a single copy in Drosophila proteins and is often associated with the MADF domain.[4][5][6]
Proteins known to contain a BESS domain include:
- Drosophila Boundary element associated factor 32 (BEAF-32).
- Drosophila Suppressor of variegation protein 3-7 (Su(var)3-7), which could play a role in chromosome condensation.
- Drosophila Ravus, which is homologous to the C-terminal part of Su(var)3-7.[7]
- Drosophila Stonewall (Stwl), a putative transcription factor required for maintenance of female germline stem cells as well as oocyte differentiation.
- Drosophila Adf-1, a transcription factor first identified on the basis of its interaction with the alcohol dehydrogenase promoter but that binds the promoters of a diverse group of genes.[4]
- Drosophila Dorsal-interacting protein 3 (Dip3). It functions both as an activator to bind DNA in a sequence specific manner and a coactivator to stimulate synergistic activation by Dorsal and Twist.[5]