BQCA

BQCA (benzyl quinolone carboxylic acid) is an experimental drug that acts as a potent and selective positive allosteric modulator of the Muscarinic acetylcholine receptor M1. It was one of the first M1-selective positive allosteric modulators to be discovered, originally developed as a potential treatment agent for cognitive symptoms of schizophrenia, and while BQCA itself was not adopted for clinical use due to its poor side effect profile it is still used in research, and has led to the discovery of a wide range of structurally related M1 PAMs.^{[1][2][3][4][5][6][7][8][9][10][11]}

CAS Number

• 338747-41-4

PubChem CID

• 1476756

ChemSpider

• 1218427

ChEBI

• CHEBI:232407

Quick facts Identifiers, CAS Number ...

BQCA

Identifiers
IUPAC name 1-[(4-methoxyphenyl)methyl]-4-oxoquinoline-3-carboxylic acid
CAS Number	338747-41-4
PubChem CID	1476756
ChemSpider	1218427
ChEBI	CHEBI:232407
ChEMBL	ChEMBL608112
CompTox Dashboard (EPA)	DTXSID20363104
Chemical and physical data
Formula	C18H15NO4
Molar mass	309.321 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC=C(C=C1)CN2C=C(C(=O)C3=CC=CC=C32)C(=O)O
InChI InChI=1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22) Key:BZBBTGCKPRSPGF-UHFFFAOYSA-N

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