BRD8

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.^[5][6][7]

AliasesBRD8, SMAP, SMAP2, p120, bromodomain containing 8

External IDsOMIM: 602848; MGI: 1925906; GeneCards: BRD8

Chr.Chromosome 5 (human)^[1]

End138,178,953 bp^[1]

Quick facts Identifiers, Aliases ...

BRD8
Identifiers
Aliases	BRD8, SMAP, SMAP2, p120, bromodomain containing 8
External IDs	OMIM: 602848; MGI: 1925906; GeneCards: BRD8
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,139,770 bp[1] End 138,178,953 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 34,731,668 bp[2] End 34,757,654 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis ventricular zone pituitary gland anterior pituitary right lobe of thyroid gland right uterine tube left lobe of thyroid gland middle temporal gyrus buccal mucosa cell Top expressed in neural layer of retina Rostral migratory stream ventricular zone tail of embryo genital tubercle spermatocyte blastocyst ganglionic eminence primitive streak yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein binding nuclear receptor activity Cellular component mitochondrion nucleus nucleoplasm Swr1 complex NuA4 histone acetyltransferase complex Biological process regulation of transcription by RNA polymerase II histone H2A acetylation regulation of growth cell surface receptor signaling pathway regulation of transcription, DNA-templated transcription, DNA-templated signal transduction histone H4 acetylation positive regulation of transcription by RNA polymerase II intracellular receptor signaling pathway chromatin organization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10902 78656 Ensembl ENSG00000112983 ENSMUSG00000003778 UniProt Q9H0E9 Q8R3B7 RefSeq (mRNA) NM_001164326 NM_001300961 NM_001300962 NM_001300966 NM_006696 NM_139199 NM_183359 NM_001289606 NM_001289607 NM_030147 NM_001361136 RefSeq (protein) NP_001157798 NP_001287890 NP_001287891 NP_001287895 NP_006687 NP_631938 NP_001276535 NP_001276536 NP_084423 NP_001348065 Location (UCSC) Chr 5: 138.14 – 138.18 Mb Chr 18: 34.73 – 34.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.^[7]