BRK1

BRK1
Identifiers
Aliases	BRK1, C3orf10, MDS027, hHBrk1, HSPC300, BRICK1, SCAR/WAVE actin nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex
External IDs	OMIM: 611183; MGI: 1915406; GeneCards: BRK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P8C, 4N78
Gene location (Human)
Chr.	Chromosome 3 (human)
End	10,127,190 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	113,593,912 bp
RNA expression pattern
	Top expressed in
	sperm; ; skin of arm; ; islet of Langerhans; ; right testis; ; monocyte; ; tibial arteries; ; left coronary artery; ; right coronary artery; ; left testis; ; smooth muscle tissue;
	Top expressed in
	medullary collecting duct; ; external carotid artery; ; endocardial cushion; ; saccule; ; internal carotid artery; ; ureter; ; renal corpuscle; ; olfactory tubercle; ; epithelium of lens; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein-containing complex binding; identical protein binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; cytoskeleton; SCAR complex; lamellipodium;
Biological process	vascular endothelial growth factor receptor signaling pathway; Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; in utero embryonic development; positive regulation of lamellipodium assembly; actin cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of cell population proliferation; protein homotrimerization; actin filament organization; cell motility; regulation of actin polymerization or depolymerization; positive regulation of protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55845
	101314
	ENSG00000254999
	ENSMUSG00000033940
	Q8WUW1
	Q91VR8
	NM_018462
	NM_133937
	NP_060932
	NP_598698
	Wikidata
View/Edit Human	View/Edit Mouse

BRICK1 is a putative micropeptide protein that in humans is encoded by the C3orf10 gene.^[5]^[6]

AliasesBRK1, C3orf10, MDS027, hHBrk1, HSPC300, BRICK1, SCAR/WAVE actin nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex

External IDsOMIM: 611183; MGI: 1915406; GeneCards: BRK1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 3 (human)^[1]

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[4]

BRK1

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