BRMS1

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesBRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator

External IDsOMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs

Chr.Chromosome 11 (human)^[1]

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BRMS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUS, 4AUV
Identifiers
Aliases	BRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDs	OMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 66,337,333 bp[1] End 66,345,125 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,091,382 bp[2] End 5,099,945 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon monocyte skin of leg skin of abdomen body of stomach body of pancreas sural nerve minor salivary glands mucosa of esophagus Top expressed in spermatid blastocyst yolk sac morula lip right kidney granulocyte embryo embryo neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone deacetylase binding protein binding NF-kappaB binding histone deacetylase activity Cellular component cytoplasm Sin3-type complex nucleus nucleoplasm Biological process positive regulation of protein deacetylation positive regulation of anoikis negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity negative regulation of transcription by RNA polymerase II histone deacetylation regulation of transcription, DNA-templated transcription, DNA-templated apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25855 107392 Ensembl ENSG00000174744 ENSMUSG00000080268 UniProt Q9HCU9 Q99N20 RefSeq (mRNA) NM_015399 NM_001024957 NM_001024958 NM_134155 NM_001374047 NM_001374048 RefSeq (protein) NP_001020128 NP_056214 NP_598916 NP_001360976 NP_001360977 Location (UCSC) Chr 11: 66.34 – 66.35 Mb Chr 19: 5.09 – 5.1 Mb PubMed search [3] [4]
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This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.^[7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.^[6]