BTBD2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.[5][6]

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BTBD2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesBTBD2, BTB domain containing 2
External IDsOMIM: 608531; MGI: 1933831; HomoloGene: 32365; GeneCards: BTBD2; OMA:BTBD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017797

NM_145361
NM_001379084

RefSeq (protein)

NP_060267

n/a

Location (UCSC)Chr 19: 1.99 – 2.03 MbChr 10: 80.48 – 80.49 Mb
PubMed search[3][4]
Wikidata
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Function

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.[6]

Interactions

BTBD2 has been shown to interact with TOP1.[7]

References

Further reading

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