BU08028

CAS Number

• 1333904-22-5

PubChem CID

• 50922685

ChemSpider

• 58145089

FormulaC₃₀H₄₃NO₄

BU08028

Identifiers
IUPAC name (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylpentan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
CAS Number	1333904-22-5
PubChem CID	50922685
ChemSpider	58145089
Chemical and physical data
Formula	C30H43NO4
Molar mass	481.677 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(C)(C)[C@](C)([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O
InChI InChI=1S/C30H43NO4/c1-6-26(2,3)27(4,33)21-16-28-11-12-30(21,34-5)25-29(28)13-14-31(17-18-7-8-18)22(28)15-19-9-10-20(32)24(35-25)23(19)29/h9-10,18,21-22,25,32-33H,6-8,11-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1 Key:HBENZIXOGRCSQN-VQWWACLZSA-N

BU08028 is a drug which acts as an extremely potent partial agonist at both the μ-opioid receptor and nociceptin receptor. It is a homologue of buprenorphine extended by just one carbon on the side chain, but has relatively greater intrinsic activity at the nociceptin receptor, which is thought to reduce the abuse potential without compromising analgesia.^[1][2][3][4]