Babycurus toxin 1

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Babycurus-toxin 1 (BcTx1) is a component of the venom of the east African scorpion Babycurus centrurimorphus. This toxin modifies both the activation and the inactivation properties of insect sodium channels.

This toxin is a component of the venom secreted by the east African scorpion Babycurus centrurimorphus of the scorpion family Buthidae, and is more specific in envenoming insects, for example the cockroach, than in human envenoming.[1]

Chemistry

The molecular weight of BcTx1 is 3248. It belongs to the long (4 C-C) scorpion toxin superfamily and can be classified as a β-toxin.[2] Only the first 30 amino acids of the BcTx1 protein have yet been sequenced.[1]

The toxin shares similarities in protein structure with other toxins found in scorpions in North Africa and the Middle East, including the genera Buthus and Centruroides.[1]

Target

Mode of action

References

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