Bacterial recombination
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Bacterial recombination is a type of genetic recombination in bacteria characterized by DNA transfer from one organism called donor to another organism as recipient. This process occurs in three main ways:
- Transformation, the uptake of exogenous DNA from the surrounding environment.
- Transduction, the virus-mediated transfer of DNA between bacteria.
- Conjugation, the transfer of DNA from one bacterium to another via cell-to-cell contact.[1][2][3][4]
The final result of conjugation, transduction, and/or transformation is the production of genetic recombinants, individuals that carry not only the genes they inherited from their parent cells but also the genes introduced to their genomes by conjugation, transduction, and/or transformation.[5][6][7]
Recombination in bacteria is ordinarily catalyzed by a RecA type of recombinase.[8] These recombinases promote repair of DNA damages by homologous recombination.[8]
The ability to undergo natural transformation is present in at least 67 bacterial species.[9] Natural transformation is common among pathogenic bacterial species.[10] In some cases, the DNA repair capability provided by recombination during transformation facilitates survival of the infecting bacterial pathogen.[10] Bacterial transformation is carried out by numerous interacting bacterial gene products.[9]
Evolution in bacteria was previously viewed as a result of mutation or genetic drift.[11] Today, genetic exchange, or gene transfer is viewed as a major driving force in the evolution of prokaryotes.[11] This driving force has been widely studied in organisms like E. coli.[12] Bacteria reproduces asexually, where daughter cells are clones of the parent. This clonal nature leads to random mutations that occur during DNA replication that potentially helps bacteria evolve.[13] It was originally thought that only accumulated mutations helped bacteria evolve.[14] In contrast, bacteria also import genes in a process called homologous recombination, first discovered by the observation of mosaic genes at loci encoding antibiotic resistance.[11] The discovery of homologous recombination has made an impact on the understanding of bacterial evolution. The importance of evolution in bacterial recombination is its adaptivity. For example, bacterial recombination has been shown to promote the transfer of multi drug resistance genes via homologous recombination that goes beyond levels purely obtained by mutation.[15]