Bacteriophage HK97
Species of virus
From Wikipedia, the free encyclopedia
Bacteriophage HK97, often shortened to HK97, is a species of virus that infects Escherichia coli and related bacteria. It is named after Hong Kong (HK), where it was first located. HK97 has a double-stranded DNA genome.
| Bacteriophage HK97 | |
|---|---|
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| Bacteriophage HK97 as seen in transmission electron microscopy (TEM), with magnification 300000x. | |
Virus classification  | |
| (unranked): | Virus |
| Realm: | Duplodnaviria |
| Kingdom: | Heunggongvirae |
| Phylum: | Uroviricota |
| Class: | Caudoviricetes |
| Genus: | Byrnievirus |
| Species: | Byrnievirus HK97[1] |
| Synonyms | |
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Assembly and maturation
The major capsid protein of HK97, called gp5, cross-links upon maturation to form a chain-mail like structure.[2]
The HK97 assembly pathway begins with self-assembly of gp5 into pentamers and hexamers. A protease, called gp4, cleaves gp5 at its N-terminus. Attachment of a portal protein, gp3, coupled with conformational changes leads to the formation of a prohead, or procapsid, which is the precursor to the mature capsid.[3] A scaffolding protein is not required for capsid assembly.[4] However, studies on the effects of deleting the delta domain of the major capsid protein, or parts of it, indicate that it is essential for assembly.[5]