Poppe began her work in the homeless sector through volunteering in Cincinnati and co-found Bethany House Services in 1983.[4] After completing her Master's in Epidemiology, Poppe worked as a Field Instructor for the University of Cincinnati in the Department of Environmental Health from July 1988 to June 1990. She was executive director of Friends of the Homeless, Inc., in Columbus, Ohio, from June 1990 to October 1995.[5]
Poppe served as executive director of the Community Shelter Board (CSB), a non-profit organization in Columbus, Ohio, from October 1995 to November 2009.[3][5]
In 2006 she received the YWCA Women of Achievement award in Columbus, Ohio.[6]
Poppe was appointed to serve as executive director of the United States Interagency Council on Homelessness in October 2009.[7] Poppe launched the first ever federal strategic plan to end homelessness "Opening Doors" in June 2020 as a roadmap for joint action by United States Interagency Council agencies to guide the development of programs and budget proposals towards a set of measurable targets to solve homelessness for veterans, adults, families, youth, and children.[8] In 2016, the U.S. Interagency Council on Homelessness announced that the number of veterans experiencing homelessness in the United States has been cut nearly in half since the launch of "Opening Doors" in 2010.[9]
She announced that she was leaving USICH February 4, 2014,[10] and on February 18, 2014, it was announced that Laura Zeilinger would replace her.[11]