Battenin

CLN3
Identifiers
Aliases	CLN3, BTS, JNCL, ceroid-lipofuscinosis, neuronal 3, battenin, BTN1, CLN3 lysosomal/endosomal transmembrane protein, battenin
External IDs	OMIM: 607042; MGI: 107537; HomoloGene: 37259; GeneCards: CLN3; OMA:CLN3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,495,575 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,585,817 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; placenta; ; granulocyte; ; blood; ; monocyte; ; epithelium of colon; ; rectum; ; right adrenal cortex; ; left adrenal gland; ; right lobe of thyroid gland;
	Top expressed in
	granulocyte; ; neural layer of retina; ; morula; ; yolk sac; ; lip; ; right kidney; ; zygote; ; choroid plexus of fourth ventricle; ; blastocyst; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; endosome; late endosome; Golgi apparatus; membrane; synaptic vesicle; Golgi membrane; plasma membrane; autophagosome; lysosomal membrane; integral component of endoplasmic reticulum membrane; trans-Golgi network; early endosome; endoplasmic reticulum; mitochondrion; caveola; membrane raft; neuron projection; Golgi stack; lysosome; nucleus;
Biological process	negative regulation of neuron apoptotic process; negative regulation of proteolysis; lysosomal lumen acidification; negative regulation of catalytic activity; galactosylceramide metabolic process; associative learning; regulation of cytosolic calcium ion concentration; neuromuscular process controlling balance; ceramide metabolic process; vesicle transport along microtubule; cellular amino acid metabolic process; neurotransmitter metabolic process; protein processing; negative regulation of apoptotic process; receptor-mediated endocytosis; lysosomal lumen pH elevation; globoside metabolic process; glucosylceramide metabolic process; autophagosome maturation; protein catabolic process; ionotropic glutamate receptor signaling pathway; action potential; membrane organization; lysosome organization; macroautophagy; amyloid precursor protein catabolic process; sphingomyelin metabolic process; vacuolar transport; transport; regulation of intracellular pH;
	Sources:Amigo / QuickGO
Orthologs
	1201
	12752
	ENSG00000188603
	ENSMUSG00000030720
	Q13286
	Q61124
NM_001286110; NM_000086; NM_001042432; NM_001286104; NM_001286105;
	NM_001286109
	NM_001146311; NM_009907; NM_001329789
NP_000077; NP_001035897; NP_001273033; NP_001273034; NP_001273038;
	NP_001273039
NP_001139783; NP_001316718; NP_034037; NP_001389644; NP_001389645;
	NP_001389646; NP_001389647; NP_001389648; NP_001389649; NP_001389650; NP_001389651
	Wikidata
View/Edit Human	View/Edit Mouse

Battenin is a protein that in humans is encoded by the CLN3 gene located on chromosome 16.^[5]^[6] Battenin is not clustered into any Pfam clan, but it is included in the TCDB suggesting that it is a transporter.^[7] In humans, it belongs to the atypical SLCs^[7]^[8] due to its structural and phylogenetic similarity to other SLC transporters.