Bentazepam
Chemical compound
From Wikipedia, the free encyclopedia
Bentazepam[1] (also known as Thiadipone, Tiadipona) is a thienodiazepine which is a benzodiazepine analog.[2]
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| Trade names | Tiadipona (ES) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral (tablets) |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Elimination half-life | 2–4 hours |
| Excretion | Renal |
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| ECHA InfoCard | 100.123.659 |
| Chemical and physical data | |
| Formula | C17H16N2OS |
| Molar mass | 296.39 g·mol−1 |
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It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around 2,5 hours after oral administration.[3] The elimination half-life is between approximately 2–4 hours.[2][4] Bentazepam is effective as an anxiolytic.
A severe benzodiazepine overdose with bentazepam may result in coma and respiratory failure.[5] Adverse effects include dry mouth, somnolence, asthenia, dyspepsia, constipation, nausea[6] and drug-induced lymphocytic colitis has been associated with bentazepam.[7][8] Severe liver damage and hepatitis has also been associated with bentazepam.[9][10][11] Whilst liver failure from bentazepam is considered to be rare, liver function monitoring has been recommended for all patients taking bentazepam.[12]
