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Benzoylhydrazine

Chemical compound From Wikipedia, the free encyclopedia

Benzoylhydrazine, also known as benzenecarbohydrazide, or benzoic hydrazide is an organic chemical compound, which is a hydrazide functionally linked to benzoic acid. It is typically used as a precursor in pharmaceutical and chemical synthesis, or used as a chemical intermediate for the production of hydrazine-based products.

Quick facts Names, Identifiers ...
Benzoylhydrazine
Names
Systematic IUPAC name
benzohydrazide
Identifiers
3D model (JSmol)
471797
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.009.423 Edit this at Wikidata
EC Number
  • 210-363-9
68991
UNII
  • InChI=1S/C7H8N2O/c8-9-7(10)6-4-2-1-3-5-6/h1-5H,8H2,(H,9,10)
    Key: WARCRYXKINZHGQ-UHFFFAOYSA-N
  • C1=CC=C(C=C1)P
Properties
C7H8N2O
Molar mass 136.154 g·mol−1
Appearance white solid
Melting point 112–117 °C (234–243 °F; 385–390 K)
Boiling point 267 °C (513 °F; 540 K)
soluble
Solubility soluble in alcohol
slightly soluble in ether, acetone, chloroform
Hazards
GHS labelling:
‹ The template below (GHS skull and crossbones) is being considered for merging with GHS pictogram. See templates for discussion to help reach a consensus. ›
GHS06: Toxic
‹ The template below (GHS exclamation mark) is being considered for merging with GHS pictogram. See templates for discussion to help reach a consensus. ›
GHS07: Exclamation mark
‹ The template below (GHS health hazard) is being considered for merging with GHS pictogram. See templates for discussion to help reach a consensus. ›
GHS08: Health hazard
Danger
H301, H315, H319, H335
P203, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
Lethal dose or concentration (LD, LC):
122 mg/kg (mouse, subcutaneous/intraperitoneal)
102 mg/kg (rabbit, subcutaneous) 100 mg/kg (rat, intraperitoneal)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Metabolism

During metabolism it forms metabolites including hydrazine, benzoic acid and hippuric acid.[1][2]

Safety

It is both neurotoxic and hepatoxic as well as an osteolathyrogen and carcinogen, and also a potential teratogen that affects the development of fetal abnormalities.[3][4][5][6][7][8][9][10]

The mechanism responsible for the development of osteolathyrism is identical to the reference osteolathyrogen β-aminopropionitrile.[8][7][9]

A violent reaction occurs with benzeneselenic acid. When heated to decomposition it emits toxic fumes of nitrogen oxides.[11][1]

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