Bezuclastinib

Bezuclastinib
Clinical data
Other names	CGT-9486, PLX-9486
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide;
CAS Number	1616385-51-3;
PubChem CID	75593308;
IUPHAR/BPS	11868;
DrugBank	DB18041;
ChemSpider	115007996;
UNII	2ROQ545LAG;
KEGG	D12600;
ChEMBL	ChEMBL5095229;
PDB ligand	WEJ (PDBe, RCSB PDB);
Chemical and physical data
Formula	C19H17N5O
Molar mass	331.379 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(NN=C1C(=O)NC2=CN=C3C(=C2)C=C(N3)C4=CC=CC=C4)C;
	InChI InChI=1S/C19H17N5O/c1-11-12(2)23-24-17(11)19(25)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,25)(H,23,24); Key:NVSHVYGIYPBTEZ-UHFFFAOYSA-N;

Bezuclastinib is an investigational new drug that is being evaluated for the treatment of gastrointestinal stromal tumors and systemic mastocytosis. It acts as an inhibitor of tyrosine-protein kinase KIT.^[1]^[2] ^[3]^[4]

Other namesCGT-9486, PLX-9486

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