Sasikanth was born in Chennai, Tamil Nadu, India to a musically affluent family. His father Murali Raj is a famous composer who composes along with his brother Sabesh as Sabesh–Murali. His uncle Deva is a popular music composer. His cousins are actor Jai and composer Srikanth Deva.
In his early stage, his uncle Deva introduced Sasikanth as a keyboard player in his movie Porkkaalam (1997).Also, he worked along with many other music directors in Tamil and Telugu industry until 2007.
His first movie for which he composed music was Kulir 100° (2009). The soundtrack won critical acclaim. Prior to the movie, he assisted other Indian film composers, such as Srikanth Deva, Sabesh–Murali, Deva, and Vidyasagar.[1] A year later, after his first film released, he started to compose music for Telugu films. His Telugu film debut was Bindaas, followed by Thakita Thakita.
In 2012, Shashi composed the music for Uu Kodathara? Ulikki Padathara?. Out of the six songs he composed in the movie, he composed five (with the sixth being composed by Vidyasagar). In 2016, he composed one song (along with Karunas) from the movie Kadavul Irukaan Kumaru, composed by G. V. Prakash Kumar. In 2018, he composed the music for Jarugandi. In 2022, he composed the music for Hostel.
