Van Belle made his professional debut in 2021 with the High-A Greenville Drive, posting a 4.10 ERA with 82 strikeouts in 18 starts.[4] He split the 2022 campaign between Greenville and the Double-A Portland Sea Dogs. In 28 games for the two affiliates, he compiled a 9–6 record and 5.31 ERA with 135 strikeouts. Van Belle split the 2023 season between Portland and the Triple-A Worcester Red Sox, totaling a 4.46 ERA with 134 strikeouts in 27 games. With Worcester in 2024, he recorded a 4.42 ERA in 30 appearances.[5]
To begin the 2025 season, Van Belle was assigned to Worcester, posting a 2.29 ERA with 41 strikeouts in 12 appearances.[6] On June 9, he was selected to Boston's 40-man roster and promoted to the major leagues for the first time.[7] On June 11, Van Belle was designated for assignment without making an appearance, becoming a phantom ballplayer.[8]
Cincinnati Reds
On June 14, 2025, Van Belle was traded to the Cincinnati Reds in exchange for cash considerations and optioned to the Triple-A Louisville Bats.[9] In seven appearances with Louisville, he accumulated a 4.95 ERA with 31 strikeouts across 36+1⁄3 innings pitched.
Tampa Bay Rays
On July 30, 2025, the Reds traded Van Belle to the Tampa Bay Rays, along with Adam Serwinowski, in exchange for Zack Littell.[10] In three starts for the Triple-A Durham Bulls, he tallied a 3-0 record and 2.04 ERA with 16 strikeouts across 17+2⁄3 innings pitched. On August 22, the Rays promoted Van Belle to the major leagues.[11] In four appearances for Tampa Bay, he logged a 1-0 record and 5.40 ERA with six strikeouts across 8+1⁄3 innings pitched. On September 6, Van Belle was placed on the injured list due to right elbow inflammation.[12] He was transferred to the 60-day injured list on September 9, officially ending his season.[13] Van Belle was designated for assignment by the Rays on November 6.[14] He cleared waivers and was sent outright to Durham on November 13.[15] Van Belle was released by the Rays organization on December 17.[16]
On January 7, 2026, Van Belle re-signed with the Rays on a two-year minor league contract.[17] On March 21, 2026, he was placed on the full-season injured list officially ending his season before it began.[18]