After the Gladstone Gallery, Donahue worked at the D’Amelio Terras Gallery before becoming a gallery director at Gavin Brown's Enterprise.[5] In 2008, she co-founded the Brooklyn gallery space Cleopatra’s with three friends.[6]
In 2015, Donahue opened her eponymous gallery in Manhattan's Lower East Side, which made a number of “Best of 2015” lists from publications such as The New York Times and Art in America magazine.[2] Bridget Donahue represents and shows contemporary artists including, as of 2019; Lisa Alvarado,[7] Susan Cianciolo, Lynn Hershman Leeson, Satoshi Kojima, Monique Mouton, Sondra Perry, Jessi Reaves, John Russell, Olga Balema Martine Syms, and Mark Van Yetter.[4] Two gallery artists were included in the 2017 Whitney Biennial: Jessi Reaves and Susan Cianciolo.[4] Martine Syms and Olga Balema were included in the 2019 Whitney Biennial curated by Rujeko Hockley and Jane Panetta.[8]