Following his graduation from Harvard, Harreld participated on consulting teams at Boston Consulting Group and aided in opening additional offices in Chicago and Munich, eventually serving as vice president and board member until 1983. He then worked as senior vice president and division president at Kraft Foods until 1993, overseeing the frozen food unit.
From 1993 to 1994, Harreld was an adjunct professor at Northwestern University. He was also president and board member at Boston Market from 1993 to 1995, a time of massive expansion for the company. Harreld later served as senior vice president at IBM from 1995 to 2008, overseeing strategic restructuring of the organization.
From 2008 to 2014, Harreld was an adjunct professor at Harvard Business School in both the entrepreneurial and strategy units. He then briefly pursued freelance business consulting. In September 2015, the Iowa Board of Regents offered him the role of president at the University of Iowa. His term began November 2, 2015. Harreld's contract was renewed until 2023 in a process described as "opaque", but he retired in 2020.[5]
Harreld's appointment to the presidency of the University of Iowa was a controversial one, with his faculty objecting to the fact that he does not possess a doctorate, had limited publications to his name, and had minimal experience working in higher education.[6] A survey undertaken in 2015 showed that fewer than 5 percent of university faculty felt that Harreld was qualified for the position.[7] In September 2015, the Faculty Senate voted no confidence in Iowa Board of Regents as a result of Harreld's appointment.[8]
The exclusion of standard faculty input from the selection process by the Iowa Board of Regents led to the University of Iowa being formally sanctioned by the American Association of University Presidents.[9] Other irregularities in the hiring process, such as the Regents' efforts to circumvent Iowa Open Meetings Law to meet secretly with Harreld on numerous occasions before his hiring, led to a lawsuit.[10]
Harreld's stance on public health and classroom safety during the COVID-19 pandemic was also a source of controversy.[11] Critics claimed that Harreld's actions increased the risk of disease transmission among the university community.[12]