Bufexamac
Chemical compound
From Wikipedia, the free encyclopedia
Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe and Australia[1] because of allergic reactions.
administrationTopical, rectal
- In general: Over-the-counter (OTC)
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Topical, rectal |
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| Pharmacokinetic data | |
| Excretion | Renal |
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| ECHA InfoCard | 100.017.683 |
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| Formula | C12H17NO3 |
| Molar mass | 223.272 g·mol−1 |
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Indications
Ointments and lotions containing bufexamac are used for the treatment of subacute and chronic eczema of the skin, including atopic eczema, as well as sunburn and other minor burns,[citation needed] and itching. Suppositories containing bufexamac in combination with local anaesthetics are used against haemorrhoids.[2]
Pharmacology
Bufexamac is thought to act by inhibiting the enzyme cyclooxygenase, which would make it a non-steroidal anti-inflammatory drug. Evidence on the mechanism of action is scarce.[3] Furthermore, bufexamac was identified as a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10).[4]
Side effects
Bufexamac can cause severe contact dermatitis which is often hard to distinguish from the initial condition.[5] As a consequence, the European Medicines Agency recommended to withdraw the marketing approval in April 2010.[6]