Butofilolol
Chemical compound
From Wikipedia, the free encyclopedia
Butofilolol (trade name Cafide) is a beta-blocker drug for the treatment of essential hypertension (high blood pressure).[1][2] It is not known to be marketed anywhere.
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| Other names | CM-6805 |
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| ECHA InfoCard | 100.055.892 |
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| Formula | C17H26FNO3 |
| Molar mass | 311.397 g·mol−1 |
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It is an example of a butyrophenone.
Synthesis
The Fries rearrangement of the ester formed by 4-fluorophenol (1)[3] and butryryl chloride (2) gives 5'-fluoro-2'-hydroxybutyrophenone (3). Treatment with epichlorohydrin in the presence of base leads to 1-[5-fluoro-2-(oxiranylmethoxy)phenyl]butan-1-one (4). Lastly, reaction with tert-butylamine gives butofilolol.[4][5]
