C-C motif chemokine ligand 24
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
C-C motif chemokine ligand 24 is a protein that in humans is encoded by the CCL24 gene.[5] CCL24 is also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2).
Function
CCL24 belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.[6] The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line.[7]
Clinical significance
Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[8]
