WAY-166818

WAY-166818
Identifiers
	IUPAC name 2-(4-Hydroxyphenyl)-1,3-benzoxazol-5-ol;
CAS Number	142629-43-4;
PubChem CID	135405741;
ChemSpider	11193037;
UNII	9R07VD5I9B;
ChEMBL	ChEMBL187392;
CompTox Dashboard (EPA)	DTXSID00465458 ;
Chemical and physical data
Formula	C13H9NO3
Molar mass	227.219 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1=CC=C(C=C1)C1=NC2=CC(O)=CC=C2O1;
	InChI InChI=1S/C13H9NO3/c15-9-3-1-8(2-4-9)13-14-11-7-10(16)5-6-12(11)17-13/h1-7,15-16H; Key:DPAMLAKLEWYMGF-UHFFFAOYSA-N;

WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research.^[1]^[2] It acts as a highly selective full agonist of the ERβ, with 57- and 164-fold selectivity for the ERβ over the ERα in the rat and mouse, respectively.^[1]^[2] At the human ERβ and ERα, WAY-166818 has IC₅₀ values of 29 nM and 1227 nM (25-fold difference), respectively.^[1] The compound has been verified to cross the blood-brain-barrier in rodents.^[1]^[2]

Quick facts Identifiers, CAS Number ...

Close

See also

Identifiers

IUPAC name 2-(4-Hydroxyphenyl)-1,3-benzoxazol-5-ol
CAS Number	142629-43-4
PubChem CID	135405741
ChemSpider	11193037
UNII	9R07VD5I9B
ChEMBL	ChEMBL187392
CompTox Dashboard (EPA)	DTXSID00465458
Chemical and physical data
Formula	C₁₃H₉NO₃
Molar mass	227.219 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES OC1=CC=C(C=C1)C1=NC2=CC(O)=CC=C2O1
InChI InChI=1S/C13H9NO3/c15-9-3-1-8(2-4-9)13-14-11-7-10(16)5-6-12(11)17-13/h1-7,15-16H Key:DPAMLAKLEWYMGF-UHFFFAOYSA-N