C6orf201

In humans, the gene is 51,558 base pairs long. The transcript that produces the longest protein of 140 amino acids is translated from unprocessed mRNA that has six exons and is 1664 nucleotides in length.^[8][9]

Chromosome 6 open reading frame 201 (C6orf201) is also referred to as: dJ1013A10.5, MGC87625, RP5-1013A10.5, and LOC404220.^[10]

C6orf201 is located on chromosome 6 at 6p25.2 position and is encoded on the plus strand.^[11] C6orf201 is located near the FAM217A gene and the ECI2 gene.^[12]

C6orf201 is highly conserved in primates, is moderately conserved in other mammals, and there is also conservation in a few reptiles.^[13] There is enough conservation in mycoplasma gallinarum to suggest that there may have been a horizontal gene transfer event sometime during the evolutionary history of C6orf201. There are no paralogs or gene duplication events for C6orf201.

C6orf201 belongs to DUF4523 (Pfam15023), a functionally uncharacterized family of proteins that is found in mammals.^[14]

Less common names of the C6orf201 protein are: protein MGC87625, hypothetical protein LOC404220, OTTHUMP00000213693, and OTTHUMP00000213725.^[10]

In humans the longest protein variant is 140 amino acids long,^[15] has a molecular weight of 16.2 kDa,^[16] and an isoelectric point of 10.88.^[16] C6orf201 is predicted to be a nuclear protein.^[7]

C6orf201 has multiple predicted PKC and CKII phosphorylation sites in humans.^[17] The protein also has a nuclear localization signal.^[7] C6orf201 has a conserved alpha helix and a conserved beta strand in the protein.^[16]

C6orf201 interacts with SRPK1,^[18] TMEM106B,^[19] and APP.^[20]