C9orf152
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| C9orf152 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | C9orf152, bA470J20.2, chromosome 9 open reading frame 152 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2442889; HomoloGene: 52276; GeneCards: C9orf152; OMA:C9orf152 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 9 open reading frame 152 is a protein that in humans is encoded by the C9orf152 gene.[5][6] The exact function of the protein is not completely understood.
The human gene C9orf152 is located on the long (q) arm of Chromosome 9.[7] Its cytogenetic location is 9q31.1. It has one known alias: bA470J20.2.[8]
The DNA sequence encoding C9orf152 contains a single intron.[7] The final mRNA consists of 2698 base pairs. Nucleotides 66-68 encode an upstream in frame stop codon.[5]
Evolution
C9orf152 has orthologs in mammals, birds, reptiles and amphibians. No orthologs have been detected in bony fish or in any invertebrates.[7][9] The following table lists a subset of conserved orthologs.
| Scientific name | Common name | Accession number | Sequence length (aa) | Percent identity | Percent similarity |
|---|---|---|---|---|---|
| Homo sapiens | Human | NP_001013011.2 | 239 | - | - |
| Pan troglodytes | Chimpanzee | XP_001145187 | 239 | 98 | 98 |
| Tarsius syrichta | Philippine tarsier | XP_008064367 | 237 | 78 | 85 |
| Ceratotherium simum simum | Rhinoceros | XP_004423784 | 239 | 78 | 82 |
| Sus scrofa | Wild boar | XP_003122117 | 239 | 74 | 83 |
| Equus caballus | Horse | XP_001491697 | 239 | 74 | 80 |
| Tursiops truncatus | Bottlenose dolphin | XP_004329084 | 234 | 73 | 81 |
| Heterocephalus glaber | Naked mole rat | XP_004903816 | 239 | 74 | 84 |
| Orcinus orca | Killer whale | XP_004269444 | 231 | 72 | 79 |
| Mus musculus | Mouse | NP_848842 | 236 | 62 | 72 |
| Rattus norvegicus | Rat | XP_003754080 | 234 | 62 | 70 |
| Chelonia mydas | Green sea turtle | XP_007059491 | 267 | 33 | 49 |
| Nestor notabilis | Kea | XP_010009525 | 265 | 34 | 49 |
| Python bivittatus | Burmese python | XP_007428415 | 234 | 30 | 44 |
| Meleagris gallopavo | Wild turkey | XP_010710660 | 267 | 29 | 43 |
| Pelodiscus sinensis | Chinese softshell turtle | XP_006120615 | 268 | 29 | 43 |
| Haliaeetus albicilla | White tailed eagle | XP_009911401 | 266 | 33 | 48 |
| Xenopus tropicalis | Western clawed frog | XP_004915565 | 226 | 31 | 45 |
Differences among shown orthologs suggest a slow rate of evolution.[10]
Protein
Chromosome 9 open reading frame 152 contains 239 amino acids. The molecular weight is 26.3 kilodaltons. The protein has a high chance of existing nuclear region of cells.[11] There are likely no transmembrane regions.[12] One isoform exists, containing 194 amino acids.[9][13]
Within the coding sequence, there are two sumoylation sites[14][15][16] and a single serine phosphorylation site.[17]
There are three regions predicted to form alpha helices on the final protein.[18][19]
